A woman took 550 times the usual dose of LSD...

...with surprisingly positive consequences.

(CNN)Drug overdoses can be life-threatening, but for two women who accidentally took massive hits of LSD, the experience was life changing -- and in a good way.

A 46-year-old woman snorted a staggering 550 times the normal recreational dose of LSD and not only survived, but found that the foot pain she had suffered from since her 20s was dramatically reduced.

Separately, a 15-year-old girl with bipolar disorder overdosed on 10 times the normal dose of the drug, which she said resulted in a massive improvement in her mental health.

Their experiences were detailed in case reports published in the Journal of Studies on Alcohol and Drugs last month, along with that of a third woman who accidentally overdosed on LSD during the second week of pregnancy. She ultimately gave birth to a healthy son, now 18, who has not shown any impaired development.

While the experiences of these women were exceptional, their stories can help inform the resurgence of research into the use of psychedelic substances for the treatment of conditions such as addiction, post-traumatic stress disorder (PTSD), depression and anxiety, the researchers believe.

"No clinical trial research could be done with dosages this high and there are no publications exploring the positive outcomes of very large dosages of LSD," the authors said.

"To understand the effects of extremely high dosages of psychedelics such as LSD, an examination of overdoses in naturalistic settings is required."

https://www.cnn.com/2020/02/27/health/lsd-overdoses-case-studies-wellnes...

I guess this is the opposite of a microdose.  Macrodose?